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Recorded in each version of ‘Chinese Pharmacopoeia’.
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Reported in ‘Shen Nong's Herbal Classic’ in around 2100 BC and Of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflataīat. Glycyrrhiza comes from the roots and rhizomes Have been extensively reported ( 10– 12). Regulatory functions, of which the anti-inflammatory activities
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TCMsīoast antioxidant, anti-inflammatory, anti-apoptotic and autophagic Numerous traditional Chinese medicines (TCMs) have been widely usedĪs preventive or therapeutic strategies in modern medicine. Widely reported, and restrict clinical application ( 8, 9). Steroids although these treatments have merits, potential risksĪnd side effects (particularly to the gastrointestinal tract) are Current treatmentsįor inflammation include non-steroidal anti-inflammatory drugs and Inflammation may become a causativeįactor for other chronic diseases, including rheumatoid arthritisĪnd atherosclerosis ( 6, 7), if not controlled. Migration, tissue breakdown and tissue repair ( 3). Mechanisms and mediators that contribute to the induction andĮxacerbation of inflammation are complex, and may involve enzymeĪctivation, mediator release, extravasation of fluid, cell Swelling, heat, and loss of function in the affected area ( 1, 2). These stimuli may induce localĪnd systemic effects, signs of which may include pain, redness, Protection of the body against burns, infections, toxic chemicals,Īllergens and other harmful stimuli. Physiological defense mechanism and is associated with the Inflammation is considered to be a primary The multi‑pathway integrated adjustment mechanism of licorice flavonoid action may reduce side effects in patients, along with any anti‑inflammatory functions, which provides a foundation for identifying and developing novel, high‑potential natural drugs with fewer side effects for clinical application. Besides classical arachidonic acid metabolism, metabolism of sphingolipids, tryptophan and fatty acids, phospholipids synthesis, and other pathways were also involved.
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A total of 9 differential endogenous metabolites associated with the therapeutic effect of licorice flavonoids were identified, including linoleic acid, sphingosine, tryptophanamide, corticosterone and leukotriene B4. On the basis of the anti‑inflammatory effects of licorice flavonoids, the potential mechanism of action was investigated via a plasma metabolomics approach. Licorice contains multiple flavonoids, which possess a variety of biological activities. Glycyrrhiza, commonly known as licorice, is a herbal medicine that has been used for thousands of years.
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